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Daily #109 · Immune / Lymphatic · Archive

NCLEX-RN® question of the day

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The question

A newborn is delivered to a mother whose hepatitis B surface antigen (HBsAg) status is positive. The nurse is preparing the infant's initial immunization plan. Which of the following statements best explains why both the hepatitis B vaccine AND hepatitis B immune globulin (HBIG) must be given within 12 hours of birth?

  1. The vaccine alone provides immediate active immunity that is sufficient to protect the newborn from vertical transmission.
  2. The HBIG provides immediate passive immunity while the vaccine stimulates the infant's own active immune response, together reducing transmission risk.
  3. The hepatitis B vaccine is given to the mother, while the HBIG is the only agent administered to the newborn.
  4. Both injections are given together because they contain the same antibodies and the double dose ensures full coverage.

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