A nurse is caring for a patient receiving their third cycle of chemotherapy for breast cancer. The patient reports feeling constantly fatigued, has developed mouth sores, and asks why their hair is falling out. Which explanation best describes why these side effects occur together during chemotherapy?

Chemotherapy targets rapidly dividing cells, which includes cancer cells as well as normal cells in the hair follicles, gastrointestinal mucosa, and bone marrow.

Chemotherapy causes an allergic response that affects the skin, mucous membranes, and hair follicles simultaneously.

Chemotherapy suppresses the immune system specifically, which allows opportunistic infections to attack hair follicles and oral tissues.

Chemotherapy disrupts the nervous system, reducing blood flow to peripheral tissues including the scalp and oral mucosa.

A nurse is preparing to administer a unit of packed red blood cells to a patient with severe anemia. Fifteen minutes after the transfusion begins, the patient reports chills, low back pain, and feeling flushed. The nurse notes the patient's temperature has risen 1.5°C from baseline. Which explanation best describes why the nurse should stop the transfusion immediately?

Low back pain, chills, and fever within minutes of starting a transfusion are classic signs of an acute hemolytic reaction caused by ABO incompatibility.

The patient is likely experiencing an allergic reaction limited to the skin requiring antihistamine administration.

These signs indicate a febrile non-hemolytic reaction, which is mild and self-limiting.

These symptoms suggest fluid volume overload from transfusing blood too rapidly.

NCLEX® Prep · Hematology & Oncology

Hematology & Oncology
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Anemia, leukemia, lymphoma, chemo side effects, transfusion reactions, and oncologic emergencies. Practice heme/onc for the NCLEX®.

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2026 NCSBN test planSBA, SATA, BowTie, CJ12 subtopics

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A nurse is preparing to administer a unit of packed red blood cells (PRBCs) to a patient with anemia. The nurse understands that blood products must be administered using specific evidence-based protocols. Which nursing action demonstrates understanding of the scientific knowledge base for safe blood transfusion administration?

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Vol. 01 · Coverage

What you'll practice

Hematology & Oncology questions span 12 subtopics aligned to the 2026 NCSBN test plan.

Anemia & Blood Disorders

Leukemia

Lymphoma

Cancer Nursing & Oncologic Emergencies

Chemotherapy Side Effects & Management

Radiation Therapy Side Effects & Management

Blood Transfusion Reactions & Administration

Bone Marrow Transplant & Immunosuppression

Tumor Lysis Syndrome & Disseminated Intravascular Coagulation

Sickle Cell Disease & Hemoglobinopathies

Coagulation Disorders & Thrombocytopenia

Polycythemia Vera & Myeloproliferative Disorders

Vol. 02 · The Method

How it works

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Jump into adaptive hematology & oncology NCLEX® practice. Lily picks questions at the right difficulty for you.
Difficulty adjusts in real time based on your answers.
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Each rationale explains why the correct answer works and why the others don't.
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Track your hematology & oncology mastery. Lily highlights weak subtopics and drills them harder until they stick.
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Vol. 03 · Questions

Common questions

How many hematology/oncology NCLEX® questions does StudyWithLily have?

Hundreds of questions covering anemia, leukemia, lymphoma, chemotherapy, radiation, transfusion reactions, bone marrow transplant, and sickle cell disease.

Does StudyWithLily cover hematology/oncology for the 2026 NCLEX®?

Yes. All heme/onc content follows the 2026 NCSBN RN Test Plan.

Can I practice hematology/oncology questions for free?

Try the sample questions above. Start free to practice heme/onc topics.

What question types are available for hematology/oncology?

SBA, SATA, BowTie, and Clinical Judgment items.

Vol. 04 · Keep Going

Practice gastrointestinal questions Practice infection control questions Turn your patho notes into practice Take a timed NCLEX® practice exam

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NCLEX® Prep · Hematology & Oncology

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Hematology & OncologyNCLEX® practice.

What you'll practice

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Common questions

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Hematology & Oncology
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